Jack,
I can't tell you anything about the O'Keefe family but I can give you some trivia that just might be of some importance.
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Arthur O'Keefe (21-Farmer) arrived at NEW YORK from LIVERPOOL on July 13, 1846 aboard the ship, MILLICETE.
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Arthur O'Keefe (37) arrived at NY fron LIMERICK on Oct 31, 1851 aboard the ship PERUVIAN
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Arthur O'Keeffe (26) arr at NY from L/P on July 6, 1850 aboard the ship ELIZA-MORRISON
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Each one of these men were traveling alone; no other O'Keefes were on these ships.
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Good Luck,
Al O'Brien