I have no connection to any of the folks listed.
There is Wilson Williford, 9, b. IL, with Louise Williford, 40, TN, in 1850 Saline Co. census. Could that be your guy? You didn't furnish any dates -- makes it much more difficult to find people.
There are other Willifords in the various censuses and in the IL Archives marriage database.
there currently are many Willifords in southern Illinois. You might consider contacting some of them.