Ruth,

Not sure if you have any census info, but it might help explain what happened to John & Sarah's children:

1870 Liberty Twp., Wells Co., Indiana
Enumeration Date: August 9, 1870
Page: 115
Line: 12
Dwelling/Family: 65/61

Hupp, John - age 30, farmer, born in OH
" Sarah E. - age 22, keeping house, born in IN
" Zippio E. - age 2, born in IN
" Ida I. - age 1, born in IN.
You listed a John S. born 1865 & Emma A. born 1866 which do not appear in the 1870 census and may indicate they are deceased by 1870.

1880 Liberty Twp., Wells Co., Indiana
Enumeration District: 145
Sheet Number: 91D
Enumeration Date: June 1, 1900
Line: 15
Dwelling/Family: 12/12

Hupp, John JR. - age 40, married, farmer, born in OH. Father born in PA. Mother born in OH
" Sarah E. - wife, age 32, married, keeping house, born in IN. Father born in OH. Mother born in IN
" Zippie E. - daughter, age 12, born in IN
" Elias C. - son, age 7, born in IN
" Linnie E. - daughter, age 6, born in IN
" Robert C - son, age 5, born in IN
It appears that by 1880 their daughters Ida I born 1869 and Lizzie M. born 1877 are deceased.

In 1900 Liberty Twp., Wells Co., IN census, John & Marie E. Hupp are living with their children Walter & Jessie. They state they have been married 17 yrs. (found a marriage record for a John Hupp to a Maria Garettson but the date is April 24, 1893 in Wells Co., IN - wonder if it is a typo because a 17 yr marriage would put the date at 1883) Another marriage for a John Hupp to a Marinda Durst took place in Wells Co., IN on July 28, 1910.
In the 1910 Liberty Twp., Wells Co., IN census John Hupp (widowed) is the head of household with his sons Walter R. & daughters Jessie M. Hupp and Linnie Little and granddaughter Marjorie Little living with him.

Indiana Death Index

Name: John Hupp
Death Date: December 15, 1915
Location: Wells County
Age: 76
Gender: Male
Book: H-18
Page: 86
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Indiana Marriage Collection 1800-1941

Name: E. Calvin Hupp
Marriage County: Wells
Birth Date: September 23
Gender: Male
Father: John
Mother: Sarah E.
Book: 8
Page: 288

E. Calvin Hupp
m: December 31, 1913 - Wells Co., IN (Bk. C-12, pg. 197)
Harriett E. Dunaway

Elias Calvin & Harriet Hupp are found in 1920 & 1930 living in Liberty Twp., Wells Co., IN with their children Minnie H., Velma B. & Marion S.
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Zippie Hupp
m: March 27, 1889 - Wells Co., IN (Bk. C-7, pg. 242)
Amos H. Neff

Amos & Zippie Neff are living in 1900 Fillmore, Montgomery Co., IL with their daughter Nellie. By 1910 & 1920 they are back in Ward 2, Bluffton, Wells Co., IN with their children Nellie J. & Nora A. By 1930 Amos is widowed and living with his daughter Nora.
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Robert Hupp
m: November 7, 1896 - Wells Co., IN (Bk. C-8, pg. 508)
Maude McClcery/McCleery

In 1900 Robert & Maude are living in Liberty Twp., Wells Co., IN with their children Arthur C. & Flo E. In 1910 Chester Twp., Wells Co., IN Arthur (age 13) is living and working as a servant in the Samuel Dickason household. In the WWI draft registration for Jun 5, 1918, Arthur states his father is Robert Cole Hupp and he works for Sinclair Oil out of El Dorado, Kansas.
Did not locate Robert, Maude or Flo in the 1910 census but found Robert's WWI draft registration and it listed his address in El Dorado, Kansas and his nearest relative to be Maude McCleery Hupp - wife. He was also working for the Sinclair Oil Co. Robert is found in the 1920 El Dorado, Butler Co. Kansas census. He is listed as age 44, married, born in IN and working as a tool dresser. Didn't locate Robert in 1930
I did find a marriage for Flo E. Hupp to Merl Markley in Wells Co., IN on August 31, 1918.
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Linnie E. Hupp
m: November 17, 1900 - Grant Co., IN (Bk. 13, pg. 170)
John A. Little

In 1900 Linnie is living in Fillmore, Montgomery Co., IL with her sister Zippie, brother-in-law Amos & niece Nellie Nepp. Found in 1910 Salamonie Twp., Huntington Co., IN with her husband John, and daughter Marjorie. In 1920 they are living in Ward 3, Bluffton, Wells Co., IN. Only one child listed, Marjorie. In 1930 they are living in Ward 2, Bluffton, Wells Co., IN.
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I hope this info helps.............Karen