Jamey
In answer to your question re: when was Lewis O'Bryan born.

Peter O'Bryan
b. circa 1730 residing in St. Mary's County MD
married
Jane Gardiner
Two sons that I know of

1. Lewis O'Bryan b. 13 Sept. 1757 Maryland
d. 13 April 1835 Bardstown KY, St. Joseph cemetary?
m. (1) Margaret Church <1779 Prince George Co. MD?)
m. (2) Mary Ann Blanford (1780 - 1816)
1 Sept 1800, Nelson Co. KY

2. William O'Bryan b. 2 June 1763 Charles Co. MD
d. 14 August 1848, Marion Co. KY, Holy Cross Cemetary ?
m. (1) Sarah Padgett (1768 - 2 March 1812) 16 Jan 1787
m. (2) Elizabeth Kincheloe, 26 April 1813 Marion Co. KY
(Nelson Co. KY ???)

This comes from a 1991 genealogy by J. E. Coomes, S.J. and from another O'Bryan from William's line.

My son comes from a whole other O'Bryan line: Philip

Katherine