I am descended from Henry Thomas Wyse, who married Nora Bragden. I have also connected with descendants of Michael/Mark Wyse, who lived in Canada. Our family story is that Andrew Wyse left Ireland at the age of 14 as a cabin boy, from the port of Cobh. We don't know when he arrived in America or where, other than finding Andrew & Jane in the 1850 census for Buffalo, NY. We also don't know when Jane arrived from New Brunswick with her family.
We will be glad to share with you what we have. I have Jane's obituary but not Andrew's. Do you have it?