I descend from Nathaniel Spence West's sister, Agnes West.
Their parents were Edward and Martha West. Edward died in Accomack Co., VA ca 1733. After his death Martha married James Fox and moved to Tyrrell Co., NC.
Martha and Edward had three known children: John, Nathaniel Spence and Agnes. Nathaniel Spence married Rebecca LNU. They had seven known children.
Agnes married John Roughton and they had eight known children.
I do not know if John married or fathered any children.
I hope this helps you.