Thank you for your lead.
I have found ELI MISHO in the 1860 PA Lycoming Williamsport Census as ELI MISHEY 27, with (his wife) Mary 27, (two daughters) Margaret E. 5, Clara M. 4, and Jno Steinbacher 25 (who I believe is his brother in law).
I have found ELI MISHO in the 1870 PA Lycoming Williamsport Census as ELY MISHOE 56, Mary 38, Margaret 15, Clara M.14. George R. 9, Hattie E. 7.
I have found him as ELIAS MISHO in 1900 PA Lycoming Loyalsock and he died in 1902.
I am looking for any information but specifically before 1860.