My DeMichele family came back and forth from Italy for a few years. I'm guessing it was to get their family settled here in the US. I have found a few ship manifests with their names.
Fredrickstown does seem to be very possible. I'm grateful for your help and all the imput that you have given in regards to locals in Pa to which most Italians imigrated to. It was all very imformative and I appreciate you going through the time and trouble.
Aquasanta Terme in the province of Ascoli Piceno in the Marche region is where the DeMichele name is still prominate in Italy. In my grandfathers marriage certificate it says that he was from Pozo which I beleive is right near Aquasanta Italy.

Sannitico, Compobasso, now Isernia, Molise Italy is also one of the places that is listed on a ship manifest. His brother was on this ship manifest.

Other regions of Italy that have been listed on the manifests are as follows: Campodipictra
South Acquasante, Italy

I was also wondering if Landsford Pa is near any of the mining places that you have mentioned in your reply to my post.
Thanks again, Sincerely: Sandy
PS I have the ship manifests in jpg form if you would like to look at them.............