Thank you so much for your reply. It is very helpful.
The two "relatives" (distant cousins) that I am most interested in were listed as working for the railroad in the 1910, 1920 and 1930 census'. George Meadows was listed as a conductor and Everette Preston Meadows was listed as an engineer. George was 49 in 1920 and Everette Preston was 47 in 1930, probably too old (?) to have known your brother-in-law.