The Cherokee roll applications show that that west VA, NC and east TN were ceded by the Cherokees before 1775. All of the Indians in the territory at that time were raiders who killed whites or were killed by whites. The newspapers of the time clearly document the fact. The government does not deny the fact that some of the applicants for the Cherokee rolls were Indian, but stated clearly that they were not Cherokee, and thus were not entitled to the compensation. However, many of the applications were rejected as fradulent in the worst case and misguided in the best case. The best record of Indians in Lee County is the 1860 census. In the 1860 census, enumerator were asked specifically to identify all free living Indians. There weren't many of them, but there were a few. The only family of the area that consistently checks out as Indian in the male line by DNA testing is the Sizemore family. If you read the Cherokee applications of Sizemore related families, it appears that only one of the NC Sizemores was claimed to be of Indian descent (not Cherokee though), and one of his male descendents was Ned Sizemore.