I, too am researching the Horners. Nathan and his wife Sarah had at least 2 children:
Charles (1822-1900). Charles married Louisa Mahaney. They lived in Wetzel County. He received a land grant in 1848. He was elected to the Virginia Legislature in 1853 & the WV Legislature in 1871. He and his wife had 10 children.
Permelia Horner (1832-1909). She was the wife of Alexander C. Ullom (my ancestor). They lived in Joseph Mills, Tyler County & had 12 children. Permelia died in 1909 of pancreatic cancer. She and her husband are buried in the Spring Hill Cemetery in Tyler County.
I think that Permelia's uncles, Charles & Isaac Jr. received land grants to what is now Wetzel County, WV in the 1820's & 30's. Permelia's brother Charles later received a land grant in Wetzel Co. in 1948, so the Wetzel County Genealogical Society had a little bit of information on him.