I have both of these surnames in my search, maybe there is a chance we can help each other. Here is some of what I have:

Dr.William Sutherlin Acker
b. 3 Feb 1805, SC. d. 21 Jun 1883, AL.
w. Elizabeth H. White
b. 24 Feb 1807, GA. d.22 Sept 1885 AL.
(nothing before or after, just wifes side going back)

now for Hughes;

William H. Hughes
b.20 Nov 1820 INdiana, d. 16 May 1866
w. Susannah Boicourt
b. 13 Aug 1829 d. Unk
Children:John Perry, Jessie H., Julia Ann, Sarah Matilda.
John Perry Hughes (my g-grandfather)
b. 7 oct 1853 ???, Clark Co., Indiana
w. Clara Jane Marcy
children: Viola (my grandmother) Samuel, Maude, and more.
See what you think...............

Thanks for you time..............
Glenda