Hi - I don't have much, but my wife's stepfather's first wife (Jean Oberle Fuller) was related to your Frank & Hannah Oberle. Her grandfather was Louis Oberle, who sounds like he was Frank's brother. Jean's grandmother was Barbera Amrhein, who sounds like she was Hannah' sister,
The 1880 census for E Union WV page 178a shows the Oberle family, with Frank & Louis and their parents Martin and Phillippa Oberle.
The 1880 census for Wheeling WV page 36d shows the Joseph & Barbera Amrhein family, with Hannah. Jean's grandmother Barbera was born in December 1880, after the census was taken