If your Ayers are from Lee Co VA they are more than likely descended from Daniel Ayers, son of Nathaniel Ayers who was b. in Wales and immigrated around 1740. This Daniel was the brother of Moses who died in Franklin co. Georgia. Daniel is found in the 1790 Lee Co.census records living near Levi Carmack. Dan Jr. married one of the Carmack girls. I am doing this from memory and my dates may not be absolutely accurate but the information can be checked out. The Nathaniel who immigrated from Wales is not the same Nathaniel as the one who was the son of the Ayers who married Mary Walker. The confusion is because someoen has listed the heirs in the Will of the VA Nathaniel as that of the nathaniel who d. in MD. The Md Nathaniel married Dorcus Cox and their children all are accounted for. Most of them moved west into Ohio and beyond. And lest anyone think that Nathaniel had more than one wife, Dorcus outlived him and at one time pics of their tombstones were available on line. That Ayers family's sire, John Ayers , b. abt 1585 in England, who married Hannah Webb Evered, arrived in Massachusetts around 1630. The family stayed in Massachusetts until one of the Ayers women and her mother in law were hanged as witches in 1692, they then moved to NJ to live with the Quakers. Most of the internet info on this John Ayers' parents is false. His parents were not Thomas Ayers and Elizabeth Rogers, but he shares a grandfather with the John on that line. The line splits 2 generations back with the Ayers who married Jane Cusse.
The Nathaniel who immigranted from Wales intermarried with Trader Thomas Payne's family. Trader Thos. Payne was also from Wales. and apparently Moses Ayers must have traveled around with Payne when he was trading with the Indians because he served as a scout for George Washington during the Indian Wars. I have worked most of the Ayers lines for over 40 years and am familiar with most of the older lines.A lot of the misinformation is the result of assumptions made when only limited info was available before the internet. Apparently many of the Ayers' took advantage of the free land grants given out by states for new arrivals. They would go across a state line, claim a grant, improve it, sell it, and move on to claim another grant. This accounts for their confusing migration patterns. If you have any questions you can contact me at mmazzeo@hughes.net.