Many people think they are related to John Wilkes Booth, but the truth is the Booth line that he belonged to was not very fruitful. John Wilkes himself never married, but he was one of twelve children born to Junius Brutus Booth, Sr. Five of those twelve children did not survive to adulthood and two never married. Of the five that did marry, four were male. Of those four men, only one had a son that survived to adulthood and married, but his only son did not survive childhood, so the Booth surname died out for this line.
Richard Junius Booth married Sarah Pearson Ware. They had one surviving son, John Baptist Booth. He married Eliza K Montaden and had 3 daughters and 1 son. Only one daughter appears to have survived to adulthood. (Booth surname died out)
Junius Brutus Booth, Jr had one surviving daughter. She married Byron Douglass and they had no surviving children. (no male survivors)
Edwin Thomas Booth (the famous actor) married (1) Mary Devlin and they had a daughter, Edwina, that married Ignatius R Grossman. They had two children. He then married Mary Frances McVicker, they had a son who died at birth. (no male survivors)
Asia Sydney Booth married John Sleeper Clarke. Of their seven children, only 4 survived to adulthood, producing 3 grandchildren. (Clake surname)
Joseph Adrian Booth married twice and had one son that died in infancy. (Booth surname died out)
Many people mistakenly believe that the family line of the English actor Barton Booth (1683-1733) is connected to the family line of John Wilkes Booth. This is not true. There was also at least one actress that claimed to be the wife of John Wilkes Booth (after he died) and there is no proof that her claim is true. His life has been examined in minute detail and there is no proof that he ever married.
There is at least one actress who used Booth as her stage name in hopes of people thinking she was in some way related to the famous actor Edwin Booth, and other’s may have done the same thing.
As for those with surnames other than Booth that believe they are connected to this line, your odds are higher of finding a connection. The females in the line were more successful in producing offspring that survived. Of course other surnames married into the family also. A great web site to check the surnames associated with the Booth family is http://colacola.tribalpages.com/