Reggio is the place to start..my grandfather was from there, Dominick Patafio, married to Maria or Mary Cuomo...
Most came here and settled in the Bronx, then drifted to Westchester County.
Many surnames connected...Romanello, Rende...good place to look in the obits...will give kids names and maiden names
From what I have heard, the name is linked to a Pope...don't know when or why, but the phrase 'prisoner of the vatican' comes to mind.
Also rumors of a connection with the infamous Borgia name, but no proof.
From what I see of my family, and the extended group on facebook and when I google the name, we are a very good looking family.
Also quite a few Patafio's in Canada.
Hope this helps..