Yes John Edward Duff was a son of John Rutherford Duff. The relevant chapters as I recall are the chapters on the London Duffs and the Elgin Duffs. There is a bit of uncertainty about the exact route of the connection between the Elgin Duffs and the descendents of Clunybeg but the authors in the Book of the Duffs seem to be in no doubt about the connection and the Royal College of Heralds when they wrote to my father about it in 1918 saw no reason to question the conclusions in the Book of the Duffs.
John Rutherford Duff as I recall was a notary who went bankrupt although his uncle continued successfully in the notarial practice of John Rutherford Duff's father, William Duff I think it was, which practice continues to this day after various mergers - under the name Cheesewrights. William Duff married Katherine McGuffong.
Both John Rutherford Duff my great great grandfather and John Edward Duff my great grandfather went bankrupt. John Edward Duff married Letitia Levitt or Levett and their daughter my grandmother was called Letitia Duff.
I now have the relevant chapter from the Book of the Duffs beside me. It is Chapter XXIX Elgin Duffs in London. The chapter starts off with Alexander Duff of Elgin, who 'was probably grandson of Daniel, third son of George of Edindiach, fourth son of Clunybeg. So there is a bit of uncertainty there although I don't think there is much doubt about the fact of the connection, only some doubt about the precise way it occurred i.e. via which brother.
On page 447 it is stated that John Edward Duff married someone called Letitia, surname unkown. This was in fact Letitia Levitt or Levett. One of their children was Letitia Duff, who married my grandfather W J Hawley, whose only son was Alan Keith Hawley, my father, and whose only daughter was Leila Hawley.
We have photos of John Edward Duff and Letitia Duff Jnr. Not sure about Letitia Duff nee Levitt without looking up.
Not sure how I invite you to view the family tree which I have started to build.