Back to looking through paperwork that I was given (as I am adopted) about my biological family. I found a write up with information about Isaac. I will type what is wrote on this paper. Came from the Encyclopedia of American Quaker Genealogy vol. V by Hinshaw. Dukemineer-----isaac b 10/30/1769 m Anna who was b 9/28/1764. their children were Hannah b 11/1/1798, Ann b 5/28/1801, Isaac b 4/24/1809.
12/1818 Elibeth (Ann) m Gershom Perdue
2/1832 Hannah m Thomas Wells
1/23/1833 Isaac dis mout.(disowned-married out of unity)
4/22/1857 Ann granted White River (granted Certificate)
says: records of meetings from Miami, Warren County, Ohio 1803
But per my information I had Isaac born in 1796. so not sure this is the same people but figured I would forward it on. Also on this page they stated that they were not sure if this was Rebecca Holmes parents but this is what they found: from the Caldwell Kentucky Marriage 1809-1900:
Lewis Holmes to Mary T. Freer March 21, 1814 and a Aaron Holmes to a Sally Terrill July 4, 1822.
Maybe this might send you in some direction.