Do you know the name of the wife of the John Holt through which your husband's line descends? There were actually two John Holts in the Bedford County, TN and adjacent areas in the early 1800s. The Bedford County, TN John Holt was married to Frances Jackson Holt. The other John Holt was married to Isabella Perkins (or something close to that) and they were first cousins.
The John Holt in Bedford County, TN died prior to about 28 August 1825. He had sons named James, John, Michael, William, Joseph, and Henry Holt and daughters named Rachael, Elizabeth, and Barbry.
I am a descendant of this John Holt through his son William Holt who married Eve Shofner.
My suggestion is that you take a look at the book, "The Descendants of Michael Holt", by Maudie Marie Holt Marshall. Some descendants apparently were in Southern Illinois and in various locations in Missouri.