There are 3 family trees at ancestry.com giving the following information.
Birth: 8 Jan 1838 - Ohio
Death: 12 Apr 1878 - Pope County (Pope), Illinois
Marriage: 5 Apr 1860 - Pope County (Pope), Illinois
Spouse: Sarah Julia Mitchell (2 trees give her name as July Ann Mitchell but they all give the same date for the marriage.)
Father: Nicholas Jeffords
Birth: ABT 1804 in Morgan Co, OH
Death: May 1846 in Pope Co., IL
Mother: Margaret Wickham
Birth: c. 1810 in Morgan Co., OH
Mary E. Jeffords
Keziah Jeffords 1832 – 1889
Henry Zane Jeffords 1836 – 1903
William Jeffords 1838 – 1878
The tree shows Margaret Wickham was Nicholas' second marriage. His first marriage was to a Charlotte Ross (1831 - ??) and they had children Sarah Ann Jeffords, Ezra Jeffords (1825 – 1903) and John David Jeffords (1827 – 1906).