Geneology work does take persistence! Thanks for the reply. Nathaniel Lyford, Charles Dana Lyford's father, built the home that I live in at 22 Vernon St. in Brookline, MA around 1851. He's listed variously on census forms as a "carpenter" or a "builder," but it's pretty clear from this house that he likely designed it himself. The general style is Italianate, but with lots of quirks. Nathaniel did own several other properties in Brookline, some of which he might have designed/built. What's your connection to the family?
Feel free to email me at nlerner AT mit.edu with more info.