I know the Manley/Nickens/Collins families intermarried. They lived in NC and TN, and some moved to southern IL. Here are the Nickens I have in my tree:
Francis "Franky" Nickens m. Joseph Manley
James Nickens m. Mary Ann Ellen Collins
Leanna Nickens m. William Collins
Malinda Nickens m. Levi Manley
Mary Nickens m. Thomas Barnes
William Nickens m. Francis ?
I think Franky's mother was related to the Scotts.