There is always a possibility that it could be the same George. Unfortunately, i have had no luck finding where any of the rest of the family went. I never found how the one child made her way from Pennsylvania to Iowa. Which is where her line ended up at. Where her siblings went is a big unknown.
It is through Hummelstown, Penn that her siblings were found as well as her parents.
In the 1860 Census you talk of, does he claim to be born in Penn? My George was born in Hummelstown, Pennsylvania in 1843. His father was also born in Penn, not sure where his mother was born at.
Would be interesting if our George's were one and the same.. but not sure how we'll find out.