I did a search in the 1850's census in Penn for this family and found them. George, who would have been aged 7, was not there. The age i have for our George was from a birth record in Hummelstown as well as his baptism record.
That he isn't in the census record in 1850 makes me wonder if he died in childhood. Unfortunately i know his mother died between 1850 and 1851, so no way of finding out how many of her children lived or died. She was born in Penn as well.
I can find the the siblings and rest of the family in Iowa by 1860.
Thinking we don't have a connection. Sorry.