My great grandfather Sam was born in Chicago in 1897; his father Giovanni (1853) was born in Agnone and was married to Diomira Dagnillo. They were married in 1880, around the same time they came over. Giovanni's father was Dominico and his mother was Rachel Ferrara. Giovanni had a brother Pietro who was born about 1870. I do not know when Dominico was born.
There could be a chance were related; however based off the current info, it's hard to say.