I continue to search for clues as to the ancestors of the "orphan" brothers of the Subject line. My grandmother was Martha Rebecca Ann Perine VanScoy, the great granddaughter of this Isaac Perine (b. 1808). I have gathered a lot of information about the Subject brothers but like others can find no definite link to their parents. I have a tentative link that follows a Perine family in Salem, VA (maybe the one near Roanoke or the one in present Harrison Co., WV) to CT and then back to Harrison Co. However, this may be a total invention on my part. I would appreciate any comments on this mystery.