My mother's maiden name was Preachers. I suspect the "s" on the end was an addition to the name Preacher at some point.
Most of the Preachers family I know of are in south Alabama or north Florida, including around Defuniak Springs, with a few in NC and SC. The family originally came from SC and NC.
So if you're looking for info on the Preacher family, I'd suggest you check out any references to Preachers too.
Sue Utter Honig