I am also researching Twiddys from the Norfolk, VA area. My grandmother is Elsie Twiddy, and she had a sister Mary Lee and a brother William Frank.
however, there were many children that their parents, Roy Lee Sr and Lillian Watson, gave birth to which were either given away or killed at birth because they couldn't afford them and Lillian was a little on the crazy side. This could be the "missing" bits that we're both looking for, and sadly there's no real record. I have family buried in Forest Lawn and Riverside Magnolia in Norfolk, who are Twiddys. There are a LOT of Twiddys in Forest Lawn (on Granby), and I've gotten pictures of many of them. I live in Norfolk, so I've been trying to connect what seems like two separate Twiddy branches *coincidentally* enough in the same city at the same time.
Aunt Mary Lee (my grandmother's sister) lived in Aylett, NC for a long time - she was a postmistress there.