The WYGALS of Wise County, West Virginia that are direct descendants of Ellis DEAN AND Martha KEITH may carry the BRCA2 mutation.

My wife and her Aunt are breast cancer survivors and have tested positive for the BRCA2 690delAA mutation. They are direct descendants of Hiram DEAN. This mutation is dominant and carriers have a 50% chance of passing it on to their offspring.

If you are in this line, and have a high rate of cancer (especially breast, ovarian and pancreatic cancer) in your WYGAL relatives, please talk to your doctor about genetic testing. Specifically mention BRCA2 690delAA as the test will be less expensive.

I don't want to scare anyone, but early detection of this mutation can save lives.