According to what I have, your John Wesley Bryan was the son of James Bryan and Elizabeth Cain. I have him born about 1834 - age 16 in the 1850 Lumpkin County Census.
My John's wife was Martha, but I don't know her maiden name.
If you would like to see the info that I have, email me at firstname.lastname@example.org
and I will send you a pdf file of James and Elizabeth Cain Bryan.