I don't know whereToughkeneman Pa. is but I will be looking it up after I close.
My line of the Macklems arrived around 1787, in Mount Bethel township, Northhampton county, Pennsylvania. This family William b. 1767 and Ann Hastings b. 1768 and their children moved on to Whitchurch, Ontario, Canada around 1805, and then my line James Macklem b. 1789 and Ann Lundy b. 1798 moved to Michigan in 1852.
I have a lot of information on these Macklems, and a little on James Macklem of Niagara Falls, Ontario, I believe this family is known as the "Chippawa Macklems". There were other Macklems that came to America in the early 1800's that were to look up William and James Macklem, but I don't know where the last Macklems went to settle.
I have know information on Macklems that went to the south. The Andrew Macklems that I show stayed in Ontario or Michigan. I would look up exact dates and locations if you wish.
Let me know if you have any questions.