John Waddell, son of James and Matilda Christie died in Forth Worth, Texas in 1933. Maybe he became a cowboy?
He was single and was buried in Greenwood cemetery.
In the 1842 census of Toronto, there is a James Waddell in St Patrick's Ward on Lot Street (now Queen St. West of Yonge)
He is an Innkeeper; 3 inmates are born in England and 4 inmates of the house are born in Ireland, and the householder has been in Canada for 10 years. 1 male single age 18 to 21; 3 males sinlge age 21 to 30; 1 male married aged 30 to 60; 1 female single aged bet 14 and 45; 1 female married aged over 45. For a total of 7 persons.
3 members of the household are Church of England, and 4 are members of Church of Scotland. It appears that 3 of the members of the households are male servants (hard to read)
1842 census is on familysearch.org
The best bet to find information about his first wife is to look in the Presbyterian records for Toronto. Many of them have been transcribed by Ontario Genealogical Society Toronto Branch. There is no record of a female Wadell buried in the non-denominational cemetery, but there was a Presbyterian cemetery in Toronto still active in 1840s and unfortunately the records of those burials are missing.
I am researching the family of Carter Waddell, who died in 1853 in Toronto, and I came across your James while eliminating other Waddell.
If I find information on James first marriage etc, I will post it. Possibly, it was announced in papers.
In the 1842-43 directory of Toronto available on OGS Toronto website
There is a James Waddle, Innkeeper on Lot Street and his Inn is called the Soldier's Inn.
You might want to check the other directory to find out when he left. Innkeepers often moved around quite a bit.
It does not look like James Waddle was still in Toronto in the3 1846-7 directory.