Completely agree with the Appalachian area and Scott/Irish connection. I'm from Chattanooga, TN but my mother's line is also I4 and they are from the Sevier County and Cocke County, TN areas as far as 1850s. I'd love to know more. I know more about the male lines of that family and I know they were largely of Scottish descent BUT judging the areas they were from it is Highly likely they did moving between Ireland and Scotland. Not through mtdna but the male lines connected to my grandmother we have Norwegian in there too. Hope to find out more as I research.