Not related. Do you have the basic census info on them? I find John and Eliza on 1920 and 1930 census in Chandler, Grady County OK. Appears John had a 1st wife in 1910 census.
I believe your Eliza is listed as daughter Elizabeth , parents James and Zada? Doss in 1910 and as Lizzie , parents James and Goda? in 1900 (terrible census to read) in Chickasha, Chickasaw Nation, Indian Territory. All census have everyone listed as "white", but that is not always the case, as census info cannot always be taken as gospel. We all know it depends on informant and recorder's intelligence, honesty, knowledge and so many other factors.
Glad to type out those census (what I can read) if you do not have them or access to them. Otherwise, good luck in your continued searches.