If you could get dates or where departure was from to immigration where in US, no ports in Indiana, would probably have come into NY, by train to other places.
Ship manifest should list if he died at sea if u can find the ship. Back trace wife....how did she get to Indiana? Census check federal and state.
Some family left out of other countries, example, I have relatives from Netherlands but did not emmigrate from Rotterdam, they left from Liverpool England. There are websites with ship manifests if you know when approximately and from where. Good luck.