According to census record, the Isaac Goldsmith I am seeking was born in Baden Germany in 1870 so it sounds like your search if for a different Isaac Goldsmith. My Isaac Goldsmith settled in Easton Pennsylvania, married Henrietta Weil and died in 1906.
Although my Isaac also had a tobacco business, it doesn't appear that he is the same Isaac that you seek. If you have additional information that might indicate that there was a relationship, you can reach me at email@example.com
In my search I have found other Isaac Goldsmiths who were also in the cigar or tobacco business that do not appear related. One in particular, I remember, was in Chicago.