Usually we get the opposite question; someone has started to do genealogy with Excel and realizes, 1, 3 or 5 months, years or days into the project, that a genealogy program would be a better tool, so they want to transform a spreadsheet into a GEDCOM.
If you have a genealogy program with good reporting features, like Roots Magic (FTM will do it too), you can create a custom report with all of the fields you are interested in, then run it on selected people and "print" to a text file, which you can import into Excel.
For instance, "print" the name, birth date, birth place, marriage date, marriage place and spouse's name for everyone who has "Pennsylvania" in any fact place. I did that when I found a data base for Pennsylvania marriages. I deleted everyone whose marriage date & place I had, then looked for the rest on the data base.
Would that strategy work to solve your problem?